Skip to main content
. 2016 Feb 4;13(3):2467–2475. doi: 10.3892/mmr.2016.4859

Figure 2.

Figure 2

A561V mutation dose-dependently suppressed the currents in HEK-293 cells stably expressing WT-hERG. (Aa) Representative whole-cell current traces obtained from cells stably expressing WT-hERG with and without varying quantities of A561V-hERG plasmid (0.8, 1.6 and 3.2 µg), as well as the currents in cells exhibiting the A561V mutation. (Ab) A portion of the voltage-clamp protocol. (B) Dose-dependent inhibition of hERG currents by the A561V mutation. (C) I–V associations of the tail currents obtained from WT-hERG cells and A561V-hERG plasmid-transfected WT-hERG cells. (D) The I–V curves were normalized to a Boltzmann function. WT, wild-type; hERG, human ether-à-go-go-related gene; I, current; V, voltage.