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. 2016 Feb 4;13(3):2467–2475. doi: 10.3892/mmr.2016.4859

Figure 4.

Figure 4

Kinetics of recovery from inactivation and deactivation analysis. (Aa) Representative current traces showing recovery from inactivation were obtained from WT-hERG and 1.6-µg A561V-transfected WT-hERG cells. (Ab) A portion of the voltage-clamp protocol. (B) Time constant (τ) values of recovery from inactivation for WT-hERG and 1.6-µg A561V-transfected WT-hERG cells. (C) Representative current recordings of deactivation in WT-hERG and 1.6-µg A561V-transfected WT-hERG cells. (D) Fast and (E) slow deactivation components of deactivation time constants (τ) as a function of test potential in WT-hERG and 1.6-µg A561V-transfected WT-hERG cells. *P<0.05, WT vs. A561V-transfected WT group. WT, wild-type; hERG, human ether-à-go-go-related gene; I, current; V, voltage.