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. 2016 Feb 4;13(3):2467–2475. doi: 10.3892/mmr.2016.4859

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Representative images of subcellular localization of the hERG protein expressed in HEK-293 cells. Top panel, HEK-293 cells expressing pEGFP-C2-WT; middle panel, HEK-293 cells expressing pEGFP-C2-A561V; and bottom panel, HEK-293 cells expressing pEGFP-C2-WT and pEGFP-C2-A561V. Left column, the hERG protein tagged with green fluorescence (green); middle column, HEK-293 cells transfected with pDsRed2-ER (red); and right column, merge of the two. Scale bar, 10 µm. GFP, green fluorescent protein; ER, endoplasmic reticulum, WT, wild-type.