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. 2016 Feb 4;13(3):2476–2484. doi: 10.3892/mmr.2016.4868

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of oxaliplatin and PT-100 combination therapy on the accumulation of CAFs in CT26 colon cancer cell-derived murine xenograft tumors. (A) Tumor growth curves. Values are expressed as the mean ± standard error of the mean. ^*P<0.05 vs. the three treatment groups. (B) Survival curves. (C) Hematoxylin and eosin staining of tumors harvested on day 22 (magnification, ×100). (D) Immunostaining for FAP, which is specifically expressed in CAFs, in tumors harvested on day 22 (magnification, ×200). (E) Detection of apoptotic cells in tumors excised on day 22 using the Deadend™ fluorometric terminal deoxynucleotidyl transferase dUTP nick end labeling system. (F) Western blot of FAP in the lysates of tumors excised on day 22. (G) Effects of oxaliplatin and PT-100 combination therapy on the expression of cytokines associated with CAFs in CT26 colon cancer cell-derived murine xenograft tumors. Tumors were resected at day 22 and the cytokine expression levels were assessed using reverse-transcription quantitative polymerase chain reaction analysis. ^*P<0.05 vs. the saline vehicle control. Values are expressed as the mean ± standard error of the mean. CAF, cancer-associated fibroblast; FAP, fibroblast activation protein.