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Expression levels of critical extracellular matrix genes. (A) Aggrecan, (B) collagen II and (C) CCN2 mRNA expression levels were markedly suppressed following treatment with recombinant CCN3 under both normal and serum deprivation conditions, as determined by reverse transcription-quantitative polymerase chain reaction. Data are presented as the mean ± standard deviation. *P<0.05. FBS, fetal bovine serum.
