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. 2016 Jan 29;13(3):2527–2535. doi: 10.3892/mmr.2016.4832

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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miR-29c targets Wnt4 and regulates cardiac differentiation through the WNT/β-catenin pathway. (A) A Luciferase assay revealed Wnt4 as a potential target of miR-29c. Expression levels of (B) Wnt4 and (C) β-catenin during P19 cell differentiation were detected using reverse transcription-quantitative polymerase chain reaction (^*P<0.05 and ^**P<0.01). The results indicated that miR-29c inhibition stimulated the WNT/β-catenin pathway and inhibited P19 cell differentiation. miR, microRNA; Wnt4, Wingless-related MMTV integration site 4.