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. Author manuscript; available in PMC: 2016 Feb 26.
Published in final edited form as: Annu Rev Biophys. 2014;43:93–117. doi: 10.1146/annurev-biophys-051013-022855

Fig. 5. Metal ion extrusion pathways of the CusA efflux pump.

Fig. 5

Four methionine pairs (C, green; O, orange; N, blue; S, yellow) in each protomer of CusA form the path of Cu(I) or Ag(I) transport. Metal ions may enter from the cytoplasmic side of the channel, via M410-M501, or through the periplasmic cleft between the sub-domains PC1 and PC2, via the three-methionine binding site M573, M623 and M672. These pathways are illustrated in black.