Table 2. MICs and EAs of the E-test and Sensititre methods compared with those of the CLSI and EUCAST methods.
Isolates (No.) | Method | Anidulafungin (μg/ml) | Caspofungin (μg/ml) | Micafungin (μg/ml) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MIC range | MIC50/90 | % EA, with respect to EUCST CLSI | MIC range | MIC50/90 | % EA, with respect to EUCST CLSI | MIC range | MIC50/90 | % EA, with respect to EUCST CLSI | |||||
C. parapsilosis (136) | EUCAST | 0.5–2 | 2/2 | 1–2 | 2/2 | 0.12–2 | 2/2 | ||||||
CLSI | 0.5–2 | 1/2 | 0.25–4 | 2/2 | 0.008–2 | 1/2 | |||||||
E-test | 0.25–4 | 1/2 | 95.6 | 99.3 | 0.25–4 | 1/2 | 98.5 | 98.5 | 0.008–2 | 0.5/1 | 93.4 | 96.3 | |
Sensititre | 0.25–2 | 1/2 | 97.8 | 100 | 0.25–2 | 0.5/1 | 88.2 | 89 | 0.015–2 | 1/1 | 96.3 | 98.5 | |
C. orthopsilosis (27) | EUCAST | 1–2 | 2/2 | 1–2 | 2/2 | 1–2 | 2/2 | ||||||
CLSI | 0.5–2 | 1/2 | 0.25–2 | 1/2 | 0.008–2 | 0.5/2 | |||||||
E-test | 0.06–4 | 1/2 | 92.6 | 96.3 | 0.25–2 | 0.5/1 | 96.3 | 100 | 0.25–2 | 0.25/1 | 63.0 | 92.6 | |
Sensititre | 0.12–2 | 0.5/2 | 92.6 | 92.6 | 0.25–1 | 0.5/1 | 77.8 | 81.5 | 0.25–2 | 0.5/2 | 66.7 | 88.9 |
CLSI, Clinical and Laboratory Standards Institute; EUCAST, European Committee on Antimicrobial Susceptibility Testing; MIC, minimum inhibitory concentration; EA, essential agreement