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. 2016 Feb 26;11(2):e0150218. doi: 10.1371/journal.pone.0150218

Table 2. MICs and EAs of the E-test and Sensititre methods compared with those of the CLSI and EUCAST methods.

Isolates (No.) Method Anidulafungin (μg/ml) Caspofungin (μg/ml) Micafungin (μg/ml)
MIC range MIC50/90 % EA, with respect to EUCST CLSI MIC range MIC50/90 % EA, with respect to EUCST CLSI MIC range MIC50/90 % EA, with respect to EUCST CLSI
C. parapsilosis (136) EUCAST 0.5–2 2/2 1–2 2/2 0.12–2 2/2
CLSI 0.5–2 1/2 0.25–4 2/2 0.008–2 1/2
E-test 0.25–4 1/2 95.6 99.3 0.25–4 1/2 98.5 98.5 0.008–2 0.5/1 93.4 96.3
Sensititre 0.25–2 1/2 97.8 100 0.25–2 0.5/1 88.2 89 0.015–2 1/1 96.3 98.5
C. orthopsilosis (27) EUCAST 1–2 2/2 1–2 2/2 1–2 2/2
CLSI 0.5–2 1/2 0.25–2 1/2 0.008–2 0.5/2
E-test 0.06–4 1/2 92.6 96.3 0.25–2 0.5/1 96.3 100 0.25–2 0.25/1 63.0 92.6
Sensititre 0.12–2 0.5/2 92.6 92.6 0.25–1 0.5/1 77.8 81.5 0.25–2 0.5/2 66.7 88.9

CLSI, Clinical and Laboratory Standards Institute; EUCAST, European Committee on Antimicrobial Susceptibility Testing; MIC, minimum inhibitory concentration; EA, essential agreement