Figure 4.
Average total (mean±SEM) WMI errors per trial (A) and WMC errors per trial (B) reflecting planned comparisons within Juvenile (G1A, I; Sham n = 8, HI + Vehicle n = 13, HI + IAIPs n = 9), Experienced Adult (G1B, II; Sham n = 8, HI + Vehicle n = 13, HI + IAIPs n = 9) and Inexperienced Adult groups (G2, III; Sham n = 7, HI + Vehicle n = 12, HI + IAIPs n = 8). Effects of Treatment within experience groups are denoted *(p<0.05) and **(p<0.01) as compared to Sham subjects. Untreated experienced HI subjects made more WMI errors as compared to shams, when working memory load was highest (trial 4) (AII). In contrast, both experienced HI groups showed persistent WMC deficits, which were shifted to trials 3 and 4 as compared to shams and their juvenile deficit profile (BII).