Table 2.
Treatment-emergent adverse events with dasatinib by organ function
| Toxicity, No. (%) | Normal N = 89 |
Liver dysfunction* N = 13 |
Renal dysfunction* N = 6 |
P | |||
|---|---|---|---|---|---|---|---|
| All | G 3/4 | All | G 3/4 | All | G 3/4 | ||
| Anemia | 80 (90) | 5 (6) | 13 (100) | 1 (8) | 6 (100) | 0 | 0.629 |
| Neutropenia | 39 (44) | 15 (17) | 7 (54) | 2 (15) | 1 (17) | 0 | 0.583 |
| Thrombocytopenia | 51 (57) | 6 (7) | 6 (46) | 2 (15) | 4 (67) | 0 | 0.494 |
| Lipase | 5 (6) | 1 (1) | 0 | 0 | 0 | 0 | 0.901 |
| Rash | 47 (53) | 0 | 7 (54) | 0 | 3 (50) | 0 | 0.988 |
| Edema | 32 (36) | 1 (1) | 2 (15) | 0 | 3 (50) | 0 | 0.558 |
| Nausea/vomiting | 33 (37) | 1 (1) | 4 (31) | 0 | 2 (33) | 0 | 0.984 |
| Diarrhea | 31 (35) | 0 | 6 (46) | 0 | 1 (17) | 0 | 0.451 |
| Liver toxicity | 45 (51) | 0 | 10 (77) | 0 | 4 (67) | 0 | 0.459 |
| Total bilirubin | 17 (19) | 0 | 3 (23) | 0 | 1 (17) | 0 | 0.930 |
| AST/ALT/ALP | 39 (44) | 0 | 9 (69) | 0 | 3 (50) | 0 | 0.546 |
| Muscle cramp | 34 (38) | 3 (3) | 6 (46) | 1 (8) | 2 (33) | 0 | 0.909 |
| Kidney toxicity | 8 (9) | 0 | 2 (15) | 0 | 3 (50) | 0 | 0.011 |
| Pleural effusion | 20 (23) | 8 (9) | 3(23) | 1 (8) | 3 (50) | 2 (33) | 0.408 |
| Bleeding | 22 (25) | 4 (4) | 3 (23) | 0 | 1 (17) | 0 | 0.911 |
| QTc prolongation | 16 (18) | 2 (2) | 1 (8) | 0 | 1 (17) | 0 | 0.897 |
*
One patient had both renal and liver dysfunction.
Abbreviations: G, grade; AST, aspartate transaminase, ALT, alanine transaminase, ALP, alkaline phosphatase.