Figure 2B; assumed number of biological replicates = 3 | ||||
hairpin | Dox | Drug | Dose | Normalized pMEK band density |
shBRAF | - | GDC-0879 | 0 | 0.1453 |
shBRAF | - | GDC-0879 | 0.1 | 0.8004 |
shBRAF | - | GDC-0879 | 1.0 | 0.1263 |
shBRAF | - | GDC-0879 | 10.0 | 0.0245 |
shBRAF | + | GDC-0879 | 0 | 0.0457 |
shBRAF | + | GDC-0879 | 0.1 | 0.6477 |
shBRAF | + | GDC-0879 | 1.0 | 0.1485 |
shBRAF | + | GDC-0879 | 10.0 | 0.0115 |
shBRAF | - | PLX4720 | 0 | 0.0795 |
shBRAF | - | PLX472 | 0.1 | 0.1615 |
shBRAF | - | PLX472 | 1.0 | 0.7760 |
shBRAF | - | PLX472 | 10.0 | 1.0721 |
shBRAF | + | PLX472 | 0 | 0.0861 |
shBRAF | + | PLX472 | 0.1 | 0.1388 |
shBRAF | + | PLX472 | 1.0 | 0.4522 |
shBRAF | + | PLX472 | 10.0 | 0.9831 |
shCRAF | - | GDC-0879 | 0 | 0.2121 |
shCRAF | - | GDC-0879 | 0.1 | 0.7038 |
shCRAF | - | GDC-0879 | 1.0 | 0.1554 |
shCRAF | - | GDC-0879 | 10.0 | 0.0239 |
shCRAF | + | GDC-0879 | 0 | 0.1005 |
shCRAF | + | GDC-0879 | 0.1 | 0.1896 |
shCRAF | + | GDC-0879 | 1.0 | 0.0933 |
shCRAF | + | GDC-0879 | 10.0 | 0.0315 |
shCRAF | - | PLX4720 | 0 | 0.4166 |
shCRAF | - | PLX472 | 0.1 | 0.7469 |
shCRAF | - | PLX472 | 1.0 | 1.1387 |
shCRAF | - | PLX472 | 10.0 | 1.2976 |
shCRAF | + | PLX472 | 0 | 0.2945 |
shCRAF | + | PLX472 | 0.1 | 0.2449 |
shCRAF | + | PLX472 | 1.0 | 0.2983 |
shCRAF | + | PLX472 | 10.0 | 0.2729 |