Groups	Variance estimate	F test statistic F(1,64) (shRNA, Dox, Drug interaction)	Partial η2	Effect size f	A priori power	Total sample size (32 groups)
Normalized pMEK in shBRAF or shCRAF cells treated with or without Dox and varying doses of GDC-0879 or PLX4720	2%	2513.61	0.97245	5.94063	99.9%	96
	15%	45.6115	0.39616	0.80999	99.9%	96
	28%	13.8318	0.16726	0.44817	99.1%	96
	40%	7.3203	0.09650	0.32681	88.4%	96