Groups	Variance estimate	F test statistic F(1,64) (shRNA, Dox)	Partial η2	Effect size f	A priori power	Total sample size (32 groups)
Normalized pMEK in shBRAF or shCRAF cells treated with or without Dox across varying doses of GDC-0879	2%	327.18	0.83639	2.26101	99.9%	96
	15%	5.81651	0.08331	0.30147	82.9%	96
	28%	1.66928	0.02542	0.16150	82.1%	320
	40%	0.81795	0.01262	0.11305	81.5%	640
Normalized pMEK in shBRAF or shCRAF cells treated with or without Dox across varying doses of PLX4720	2%	7267.4	0.99127	10.6561	99.9%	96
	15%	129.198	0.66873	1.42082	99.9%	96
	28%	37.0786	0.36683	0.76115	99.9%	96
	40%	18.1685	0.22111	0.53281	99.9%	96