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. 2015 Jun 26;27(3):699–705. doi: 10.1681/ASN.2014100971

Figure 1.

Figure 1.

RAS blockade regenerates kidney vasculature. (A) Diagram of the experimental design. (B) Representative three–dimensional views of kidney vasculature by ex vivo microCT in 50- and 60-week-old MWF rats compared with 50-week-old Wistar rats and representation of intermediate– and small–sized capillary beds. (C) Quantification of vascular and kidney volume (top panel), vessels with diameter ranging from 80 to 180 μm (middle panel), and vessels with diameter <80 μm (bottom panel). (D) Representation of kidney vasculature in MWF rats on treatment with lisinopril and losartan. (E) Equivalent vessel length of blood vessels with diameters ranging from 80 to 180 μm (upper panel) and <80 μm (lower panel). (F) Quantification of capillary volume density (Vv) as a percentage of Reca1 positivity in interstitial (upper panel) and glomerular (lower panel) areas. Values are means±SDs; n=5 for Wistar and MWF50 rats, n=10 for untreated MWF60 rats and MWF rats treated from 50 to 60 weeks of age with lisinopril, and n=7 for MWF rats treated from 50 to 60 weeks of age with losartan. *P<0.05 versus MWF60; **P<0.01 versus MWF60; °P<0.05 versus MWF50; °°P<0.01 versus MWF50. LIS, lisinopril; LOS, losartan; Reca1, rat endothelial cell antigen 1.