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. 2015 Jul 1;27(3):914–923. doi: 10.1681/ASN.2014111114

Table 4.

Sensitivity analyses

Period after Hospital Discharge (d)
180 365 540 730
Sensitivity analysis 1: Excluding patients who were receiving antihypertensive drugsa at the time of hospital admission
 n 32,351 34,060 34,563 34,754
 No. of subjects with AKI 1557 1602 1611 1621
 Adjustedb OR for elevated BP postdischarge,c AKI versus no AKI 1.39 1.36 1.28 1.22
  95% CI 1.24 to 1.56 1.22 to 1.52 1.15 to 1.42 1.10 to 1.36
Sensitivity analysis 2: Excluding patients who had eGFR<60 ml/min per 1.73 m2 or documented prior proteinuria before hospitalization
 n 33,277 35,023 35,518 35,690
 No. of subjects with AKI 1547 1588 1596 1602
 Adjustedd OR for elevated BP postdischarge,c AKI versus no AKI 1.48 1.38 1.29 1.20
  95% CI 1.32 to 1.66 1.23 to 1.53 1.16 to 1.43 1.08 to 1.34
Sensitivity analysis 3: Outcome of elevated BP more strictly defined as ambulatory SBP >140 mmHg and/or ambulatory DBP >90 mmHg at two separate visits
 n 40,861 42,845 43,407 43,611
 No. of subjects with AKI 2367 2426 2438 2451
 Adjustedb OR for elevated BP postdischarge, AKI versus no AKI 1.73 1.55 1.47 1.45
  95% CI 1.53 to 1.95 1.40 to 1.73 1.34 to 1.63 1.32 to 1.59
Sensitivity analysis 4: AKI defined only using (peak inpatient creatinine)/(baseline creatinine)≥1.5 and excluding patients who met AKI criteria solely because of (peak inpatient creatinine)−(baseline creatinine)≥0.3 mg/dl
 n 40,861 42,845 43,407 43,611
 No. of subjects with AKI 1652 1686 1695 1704
 Adjustedb OR for elevated BP postdischarge,c AKI versus no AKI 1.47 1.41 1.31 1.28
  95% CI 1.32 to 1.64 1.27 to 1.57 1.19 to 1.46 1.15 to 1.41
Sensitivity analysis 5: Outcome of elevated BP defined as ambulatory SBP >140 mmHg and/or ambulatory DBP >90 mmHg during follow-up after excluding all BP values during the first 90 d postdischarge
 n 26,922 36,937 39,539 40,340
 No. of subjects with AKI 1575 2009 2111 2153
 Adjustedb OR for elevated BP postdischarge, AKI versus no AKI 1.37 1.35 1.28 1.24
  95% CI 1.21 to 1.56 1.22 to 1.50 1.17 to 1.41 1.13 to 1.36

SBP, systolic BP; DBP, diastolic BP.

a

Antihypertensive drugs included here are diuretics, β-blockers, calcium channel blockers, angiotensin–converting enzyme inhibitors, and angiotensin II receptor blockers.

b

Adjusted for age at index hospitalization, sex, race, body mass index, last ambulatory systolic and diastolic BP measurements, smoking status, diabetes mellitus, chronic heart failure, coronary heart disease, last ambulatory eGFR, and proteinuria.

c

Defined as systolic BP>140 mmHg and/or diastolic BP>90 mmHg during follow-up.

d

Adjusted for age at index hospitalization, sex, race, body mass index, last ambulatory systolic and diastolic BP measurements, smoking status, diabetes mellitus, chronic heart failure, coronary heart disease, and last ambulatory eGFR.