Table 1.
Population characteristics
| Characteristics | Total Population (n=2645) | eGFRcrcys (ml/min per 1.73 m2) | ||
|---|---|---|---|---|
| <60 (n=80) | 60–90 (n=1459) | >90 (n=1106) | ||
| Age, yr | 56.6 (6.4) | 66.8 (10.1) | 57.8 (6.3) | 54.3 (4.8) |
| Men | 1186 (44.8) | 31 (38.8) | 621 (42.6) | 534 (48.3) |
| Systolic BP, mmHg | 132.0 (18.5) | 143.6 (23.3) | 132.5 (18.4) | 130.5 (17.2) |
| Diastolic BP, mmHg | 82.3 (10.8) | 84.2 (11.3) | 82.2 (11.1) | 82.3 (10.3) |
| Body mass index, kg/m2 | 27.5 (4.3) | 29.3 (5.0) | 27.7 (4.3) | 26.9 (4.1) |
| Alcohol | ||||
| Moderate drinker | 1593 (60.2) | 46 (57.5) | 900 (61.7) | 647 (58.5) |
| Heavy drinker | 783 (29.6) | 17 (21.3) | 407 (27.9) | 359 (32.5) |
| Smoking | ||||
| Current | 689 (26.0) | 19 (23.8) | 384 (26.3) | 286 (25.9) |
| Former | 1157 (43.7) | 42 (52.5) | 627 (43.0) | 488 (44.1) |
| Total cholesterol, mmol/L | 5.6 (1.0) | 5.4 (1.1) | 5.6 (1.0) | 5.5 (1.0) |
| HDL, mmol/L | 1.4 (0.4) | 1.3 (0.3) | 1.4 (0.4) | 1.4 (0.4) |
| MMSE, points | 28 [27–29] | 28 [27–29] | 28 [27–29] | 28 [27–29] |
| Diabetes mellitus | 206 (7.8) | 18 (22.5) | 96 (6.6) | 92 (8.3) |
| History of coronary heart disease | 92 (3.5) | 8 (10.0) | 54 (3.7) | 30 (2.7) |
| History of stroke | 35 (1.3) | 4 (5.0) | 21 (1.4) | 10 (0.9) |
| Dementia | 9 (0.3) | 3 (3.8) | 5 (0.3) | 1 (0.1) |
| Antihypertensive medication | 582 (22.0) | 48 (60.0) | 340 (23.3) | 194 (17.5) |
| Lipid-lowering medication | 556 (21.0) | 28 (35.0) | 329 (22.5) | 199 (18.0) |
| GFRcr, ml/min per 1.73 m2 | 86.1 (13.3) | 53.5 (13.0) | 80.6 (10.1) | 95.8 (8.1) |
| GFRcys, ml/min per 1.73 m2 | 86.2 (15.8) | 47.4 (10.2) | 78.4 (10.8) | 99.3 (8.8) |
| GFRcrcys, ml/min per 1.73 m2 | 86.3 (13.4) | 49.4 (10.0) | 79.0 (7.2) | 98.5 (6.2) |
| Albumin-to-creatinine ratio, mg/g | 3.4 [2.2–6.1] | 5.9 [2.8–19.0] | 3.4 [2.2–6.1] | 3.5 [2.1–5.9] |
| CBF, ml/min per 100 ml brain volume | 58.5 (9.7) | 54.7 (10.2) | 58.4 (9.7) | 59.0 (9.7) |
Categorical variables are number (percentage), and continuous variables are mean (SD). Albumin-to-creatinine ratio is as presented as median [interquartile range]. The following variables had missing data: BP (n=9), smoking (n=5), alcohol (n=12), lipid-lowering medication (n=24), antihypertensive medication (n=24), HDL cholesterol (n=7), total cholesterol (n=5), history of cardiovascular disease (n=28), body mass index (n=2), hypertension (n=24), and dementia (n=3). CBF, cerebral blood flow.