Table 2.
Association of measures of kidney function with cerebral blood flow (ml/min per 100 ml brain volume)
| Regression Models | Cerebral Blood Flow (ml/min per 100 ml Brain Volume) | |
|---|---|---|
| Differencea (95% CI) | P Value | |
| Albumin-to-creatinine ratio (n=2797) | ||
| Model I | −0.31 (−0.58 to −0.03) | 0.02 |
| Model II | −0.24 (−0.52 to 0.05) | 0.10 |
| Model II | −0.18 (−0.48 to 0.12) | 0.24 |
| eGFRcrcys (n=2645) | ||
| Model I | 0.37 (−0.03 to 0.77) | 0.07 |
| Model II | 0.42 (0.01 to 0.83) | 0.04 |
| Model III | 0.49 (0.06 to 0.93) | 0.02 |
| eGFRcr (n=2840) | ||
| Model I | 0.48 (0.11 to 0.85) | 0.01 |
| Model II | 0.48 (0.11 to 0.87) | 0.01 |
| Model III | 0.58 (0.18 to 0.97) | <0.01 |
| eGFRcys (n=2724) | ||
| Model I | 0.09 (−0.32 to 0.51) | 0.65 |
| Model II | 0.12 (−0.31 to 0.55) | 0.58 |
| Model III | 0.16 (−0.29 to 0.61) | 0.49 |
Model I is adjusted for age and sex. Model II is additionally adjusted for systolic BP, diastolic BP, body mass index, alcohol consumption, smoking, total cholesterol, HDL cholesterol, cardiovascular disease, diabetes mellitus, MMSE, antihypertensive medication, and lipid-lowering medication. Model III is additionally adjusted for eGFRcrcys in analyses with albumin-to-creatinine ratio as the determinant and additionally adjusted for albumin-to-creatinine ratio in analyses with eGFR as the determinant. Each SD for eGFRcrcys=13.4, each SD for eGFRcys=13.8, and each SD for eGFRcr=13.3.
Differences (β-values) are calculated per each SD increase in eGFR. β-Values for albumin-to-creatinine ratio represent cerebral blood flow values (milliliters per minute per 100 ml brain volume) per doubling of the albumin-to-creatinine ratio.