Table 3.
Association of kidney function markers with prevalence of stroke and dementia in categories of cerebral blood flow
| Regression Models | Stroke or Dementia Prevalence Odds Ratio (95% CI)a | P Value for Interaction | ||
|---|---|---|---|---|
| Total Population | Low CBF | High CBF | ||
| eGFRcrcys | ||||
| Model I | 1.38 (1.02 to 1.87) | 1.62 (1.11 to 2.36) | 1.02 (0.58 to 1.79) | 0.02 |
| Model II | 1.35 (0.98 to 1.86) | 1.63 (1.07 to 2.48) | 1.05 (0.60 to 1.84) | 0.03 |
| Albumin-to-creatinine ratio | ||||
| Model I | 1.18 (1.01 to 1.37) | 1.21 (1.01 to 1.45) | 1.09 (0.82 to 1.45) | 0.14 |
| Model II | 1.07 (0.90 to 1.27) | 1.07 (0.87 to 1.32) | 1.05 (0.76 to 1.44) | 0.53 |
Cutoff for cerebral blood flow is 57 ml/min per 100 ml brain volume. Model I is adjusted for age and sex. Model II is additionally adjusted for systolic BP, diastolic BP, body mass index, alcohol consumption, smoking, total cholesterol, HDL cholesterol, cardiovascular disease, diabetes mellitus, MMSE, antihypertensive medication, and lipid-lowering medication. Each SD for eGFRcrcys=13.4. CBF, cerebral blood flow.
a
Odds ratios are presented per each negative SD of eGFRcrcys and per doubling of the albumin-to-creatinine ratio.