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. 2015 Sep 16;27(3):766–780. doi: 10.1681/ASN.2014121196

Figure 1.

Figure 1.

Hyponatremia without brain cell swelling was induced in rats. (A) Experimental protocol. Injection of saline (control group) or 1-deamino-8-d-arginine vasopressin (dDAVP) (hyponatremia group) was started on day 0 and rats were fed a liquid diet from day 2. Experiments were performed after day 6. (B) Serum sodium concentrations in control (n=11), moderately hyponatremic (n=9) and severely hyponatremic (n=9) rats. One-way ANOVA followed by Fisher’s projected least significant difference test; **P<0.01. (C) Body weights in control (n=9), moderately hyponatremic (n=8) and severely hyponatremic (n=6) rats over time. Two-way ANOVA. (D) Ratio of brain apparent diffusion coefficient values before and after induction of hyponatremia (control n=6, chronically severe hyponatremia n=6, acute hyponatremia n=8). One-way ANOVA followed by Fisher’s projected least significant difference test; *P<0.05, **P<0.01. NS, not significant.