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. 2015 Sep 16;27(3):766–780. doi: 10.1681/ASN.2014121196

Figure 5.

Figure 5.

Chronic hyponatremia impairs long-term potentiation (LTP) in hippocampal CA3–CA1 synapses. (A and B) The magnitude of LTP induced in moderately hyponatremic rats (n=12) is significantly smaller as compared with control (n=10) rats. (A) Plots of normalized field excitatory postsynaptic potential (fEPSP) slopes. (B) The average percentage change of fEPSP slopes before and 60–69 minutes after high frequency stimulation (HFS). Student’s t test; *P<0.05 versus control. (C) Input-output curve (input is given by the amplitude of stimulus intensity applied in the Schaffer collateral/commissural pathway and output is given by the amplitude of fEPSP) of moderately hyponatremic (n=12) and control (n=10) rats. Two-way ANOVA. (D) Paired-pulse ratio of moderately hyponatremic (n=12) and control (n=10) rats. The graph shows the averaged ratio of consecutive fEPSP amplitudes (second fEPSP amplitude/first fEPSP amplitude). Student’s t test; NS, not significant.