Skip to main content
. 2015 Jul 9;27(3):792–803. doi: 10.1681/ASN.2015010009

Figure 3.

Figure 3.

Bone marrow–derived monocytes protect against damage to kidney tissue during sepsis. (A) Quantification of kidney histologic lesions 24 hours after CLP in WT, Ccr2−/− and Ccr2−/− mice with adoptive transfer of WT bone marrow monocytes before surgery. Bars represent mean±SD (n=10 WT, 11 Ccr2−/−, 9 WT in Ccr2−/−; data from at least two repeated experiments; ANOVA with Bonferroni adjustment was used; ****P<0.0001). (B) Survival of CLP-operated Cx3cr1−/− mice after adoptive transfer of WT (gray line) or Cx3cr1−/− bone marrow monocytes (black line) (n=7 per group out of three independent experiments; survival curves were compared with a log-rank test; *P<0.05). (C) Quantification of kidney histologic lesions 24 hours after CLP in Cx3cr1−/− mice with adoptive transfer of WT (gray) or Cx3cr1−/− (black) bone marrow monocytes before surgery (n=9 per group from at least two repeated experiments; ANOVA with Bonferroni adjustment was used; **** P<0.0001).