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. 2015 Jul 9;27(3):792–803. doi: 10.1681/ASN.2015010009

Figure 6.

Figure 6.

The proadhesive CX3CR1 I249 allele is associated with a reduced incidence of AKI in septic patients. PBMCs from individuals with CX3CR1 VV (black) or VI (gray) genotypes were assayed for adhesion with (A) CX3CL1-expressing HEK (n=9–10 individuals) or (B) with adherent smooth muscle cells (SMCs) treated with TNF-α and IFN-γ (n=5 individuals in each group). Bars indicate mean±SEM. A t test was used; *P<0.05. (C) V249I polymorphism distribution and incidence of AKI in patients with VV− (black bar) or VI/II− (gray bar) polymorphisms (n=239; chi-squared test was used; and 95% confidence intervals of the estimate are presented).