Table 3.

Multivariate Cox analysis

Variable	Patients (n)	HR (95% CI)	95% CI from Bootstrap Analysis	P Value	Points for PROPKD Score
Sex
Female	541				0
Male	432	1.55 (1.29 to 1.88)	1.27 to 1.89	<0.001	1
Hypertension before age 35 yr
No	679				0
Yes	294	2.11 (1.71 to 2.61)	1.71 to 2.62	<0.001	2
≥1 urologic event before age 35 yr
No	734				0
Yes	239	1.73 (1.38 to 2.18)	1.35 to 2.24	<0.001	2
Mutation
PKD2	186				0
PKD1 nontruncating	239	2.27 (1.57 to 3.28)	1.61 to 3.18	0.002	2
PKD1 truncating	548	4.75 (3.41 to 6.60)	3.63 to 6.60	<0.001	4

95% CI, 95% confidence interval.