Table 3.
Characteristics of siblings of women who had hypertension in pregnancy, and men and women from families in which no sister had hypertension in pregnancy
| Characteristic | Women whose sister(s) had hypertension in pregnancy (n=353) | Women whose sister(s) did not have hypertension in pregnancy (n=1070) | P Value | Men whose sister(s) had hypertension in pregnancy (n=235) | Men whose sister(s) did not have hypertension in pregnancy (n=684) | P Value |
|---|---|---|---|---|---|---|
| Race | 0.21 | 0.25 | ||||
| Non-Hispanic white | 91 (26%) | 326 (31%) | 79 (34%) | 258 (38%) | ||
| Non-Hispanic black | 145 (41%) | 397 (37%) | 72 (31%) | 173 (25%) | ||
| Hispanic | 117 (33%) | 347 (32%) | 84 (36%) | 253 (37%) | ||
| Age (years) | 56±11 | 61±10 | <0.001 | 56±10 | 61±10 | <0.001 |
| BMI (kg/m2) | 32.5±7.0 | 31.4±6.7 | 0.01 | 30.5±5.6 | 30.1±5.3 | 0.35 |
| Education | 0.37 | 0.40 | ||||
| Less than high school (≤8 years) | 82 (23%) | 274 (26%) | 69 (29%) | 213 (31%) | ||
| Some high school (9–11 years) | 39 (11%) | 117 (11%) | 38 (16%) | 81 (12%) | ||
| High school graduate/GED (12 years) | 97 (28%) | 323 (30%) | 54 (23%) | 167 (24%) | ||
| Post high school (>12 years) | 135 (38%) | 356 (33%) | 74 (31%) | 223 (33%) | ||
| Ever smoked | 95 (27%) | 357 (33%) | 0.02 | 164 (70%) | 469 (69%) | 0.75 |
| Hyperlipidemia | 223 (64%) | 718 (68%) | 0.16 | 142 (61%) | 442 (65%) | 0.26 |
| Diabetes | 107 (30%) | 345 (32%) | 0.50 | 65 (28%) | 230 (34%) | 0.09 |
| Family history of hypertension | 270 (77%) | 754 (70%) | 0.03 | 176 (75%) | 410 (60%) | <0.001 |
| Family history of CHD | 181 (51%) | 452 (42%) | 0.01 | 106 (45%) | 310 (45%) | 0.95 |
| Family history of stroke | 117 (33%) | 336 (31%) | 0.54 | 69 (29%) | 192 (28%) | 0.71 |
| Family history of CHD/stroke | 235 (67%) | 626 (59%) | 0.01 | 140 (60%) | 402 (58%) | 0.83 |
| Parity (% nulliparous) | 42 (12%) | 101 (9%) | 0.22 | NA | NA |
Values are mean±SD, or n (% of total). Women who had hypertension in pregnancy were not included in statistical comparisons. The first column includes all women who were nulliparous or had normotensive pregnancies, and came from a family in which at least one sister had hypertension in pregnancy. The second column includes all nulliparous and parous women from families in which no sister had hypertension in pregnancy. The fourth column includes all men from families in which at least one sister had hypertension in pregnancy. The fifth column includes all men from families in which there was at least one parous sister, and no sister had hypertension in pregnancy. CHD, coronary heart disease; GED, general educational development.