Table 4.
Effect of a sibling history of hypertension in pregnancy on disease risk in women who were nulliparous or had normotensive pregnancies
| Outcome | Women whose sister(s) had hypertension in pregnancy (n=353) | Women whose sister(s) did not have hypertension in pregnancy (n=1070) | HRb (95% CI) | P Value | ||
|---|---|---|---|---|---|---|
| Unadjusted prevalence | Adjusted prevalencea | Unadjusted prevalence | Adjusted prevalencea | |||
| Hypertensionc | 129 (62.9%) | 68.6% | 707 (66.1%) | 65.7% | 1.15 (1.04–1.26) | 0.01 |
| CHDd or stroke | 28 (7.9%) | 10.1% | 109 (10.2%) | 9.4% | 1.09 (0.88–1.35) | 0.44 |
| CHDd | 18 (5.1%) | 6.4% | 82 (7.7%) | 7.2% | 0.96 (0.76–1.30) | 0.96 |
| Stroke | 10 (2.8%) | 3.7% | 36 (3.4%) | 3.1% | 1.12 (0.77–1.63) | 0.56 |
Values are n/total (%). Specific inclusion criteria for each group of women are listed in the footnote to Table 3. Results were not different when nulliparous women were excluded, and when analyses were adjusted for intrafamilial correlation of outcomes (data not shown). CHD, coronary heart disease.
Adjusted for age, BMI, smoking, family history of the outcome and total number of parous full sisters in the family.
Adjusted for BMI, smoking, family history of the outcome and total number of parous full sisters in the family.
One hundred and forty-seven women whose sister(s) were diagnosed with hypertension prior to or during the year of their first hypertensive pregnancy were excluded from the analysis.
CHD defined as myocardial infarction, angioplasty, bypass, stent, or balloon angioplasty.