Figure 2.

CHD2 Recruitment to DNA Damage Requires PARP1

(A) Recruitment of CHD2-GFP to multi-photon tracks in U2OS cells treated with DMSO or 1 μM PARPi.

(B) Quantification of (A).

(C) Recruitment of endogenous CHD2 in U2OS cells treated with DMSO or 10 μM PARPi.

(D) Recruitment of CHD2-GFP in cells transfected with the indicated siRNAs.

(E) Western blot showing PARP1/2 knockdown efficiency in cells from (D).

(F) Quantification of (D). 30–170 cells were analyzed from three independent experiments.