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. 2015 Dec 23;157(3):1187–1199. doi: 10.1210/en.2015-1711

Figure 1.

Figure 1.

Cort disrupts estrous cyclicity in the female mouse. A, Mean serum Cort measured on the final day of implantation in Veh- and Cort-treated female mice. B, Representative profiles depicting estrous cyclicity in female mice, as measured by vaginal cytology, before (d 1–22, baseline) and during the period of implantation (d 23–38, implant) with a cholesterol (Veh, top panel) or Cort pellet (2 lower panels). P, proestrus; E, estrus; M, metestrus; D, diestrus. C, Average estrous cycle length during the baseline and implant periods in female mice treated with Veh or Cort. D, Average time spent in each stage of the cycle during the baseline and implant periods in Veh and Cort mice; n = 6 animals/group. Values were analyzed by one- or two-way ANOVA with group (Veh vs Cort) and time (baseline period vs implant period) as factors. *, P < .001, Veh vs Cort.