Table 3b. Univariate Analysis for Predictors of Venous Thromboembolism in Cancer Patients, Adjusting for Cancer Site VTE Risk Score, Individual Cancer Sites and Cancer Stage (Table 3a).
| Characteristic | OR | 95% CI* | p-value* | |
|---|---|---|---|---|
|
| ||||
| Stage change | 1.99 | 1.39 | 2.85 | <.001 |
|
| ||||
| Metastasis | 1.70 | 1.27 | 2.29 | <.001 |
|
| ||||
| Metastasis to liver | 2.62 | 1.81 | 3.79 | <.001 |
|
| ||||
| Metastasis to bone | 1.56 | 1.05 | 2.32 | 0.027 |
|
| ||||
| Cancer grade 3 or 4 | 1.38 | 1.04 | 1.82 | 0.026 |
|
| ||||
| Chemotherapy | 1.76 | 1.27 | 2.45 | <.001 |
|
| ||||
| Radiation therapy | 1.77 | 1.00 | 3.15 | 0.051 |
|
| ||||
| Progestins | 1.76 | 1.03 | 2.99 | 0.038 |
|
| ||||
| Age, 10-year increase | 0.67 | 0.43 | 1.06 | 0.084 |
|
| ||||
| BMI (continuous variable) | 0.99 | 0.97 | 1.02 | 0.67 |
|
| ||||
| BMI (categorical; Reference: 18.5-25 kg/m2) | ||||
| BMI <18.5 kg/m2 (Underweight) | 1.93 | 1.18 | 3.17 | 0.009 |
|
| ||||
| BMI 25-30 kg/m2 (Overweight) | 0.87 | 0.64 | 1.18 | 0.38 |
|
| ||||
| BMI 30-35 kg/m2 (Obese class I) | 1.13 | 0.74 | 1.72 | 0.58 |
|
| ||||
| BMI >35 kg/m2 (Obese class II-III) | 1.70 | 0.89 | 3.25 | 0.11 |
|
| ||||
| Location of onset of VTE (Reference: Community) | ||||
| Hospitalized | 10.87 | 6.48 | 18.22 | <.001 |
|
| ||||
| Hospitalization within 92 days | 4.94 | 3.37 | 7.24 | <.001 |
|
| ||||
| Nursing Home/no hospitalization | 4.46 | 1.92 | 10.34 | <.001 |
|
| ||||
| ICU stay | 5.26 | 2.79 | 9.91 | <.001 |
|
| ||||
| General surgery | 2.28 | 1.57 | 3.31 | <.001 |
|
| ||||
| Neurosurgery | 8.48 | 0.93 | 77.52 | 0.058 |
|
| ||||
| Orthopedic surgery | 3.75 | 1.34 | 10.46 | 0.012 |
|
| ||||
| Gynecologic surgery | 2.32 | 1.09 | 4.95 | 0.028 |
|
| ||||
| General/cardiac/orthopedic/neuro/gynecologic surgery |
3.27 | 2.25 | 4.74 | <.001 |
|
| ||||
| Any anesthesia | 2.91 | 2.09 | 4.06 | <.001 |
|
| ||||
| Superficial vein thrombosis | 1.91 | 1.28 | 2.87 | 0.002 |
|
| ||||
| Chronic renal disease | 2.92 | 0.92 | 9.30 | 0.069 |
|
| ||||
| Neurologic disease | 6.45 | 2.49 | 16.69 | <.001 |
|
| ||||
| Any heart disease | 1.41 | 1.04 | 1.90 | 0.026 |
|
| ||||
| Autoimmune connective tissue disease | 3.50 | 1.18 | 10.37 | 0.024 |
|
| ||||
| Trauma/fracture | 2.17 | 1.11 | 4.24 | 0.024 |
|
| ||||
| Immobilization | 3.73 | 2.00 | 6.93 | <.001 |
|
| ||||
| Central vein catheter | 18.73 | 5.36 | 65.48 | <.001 |
|
| ||||
| Any Infections | 3.06 | 2.24 | 4.19 | <.001 |
*
95% Confidence intervals are calculated using the robust sandwich estimate of Lin and Wei [54] for the covariance and standard error. P-values are Wald p-values from the conditional logistic model using the robust sandwich estimate. Covariates that reached the statistical significance level p≤0.1 are included in this table.