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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Immunol Rev. 2016 Jan;269(1):145–161. doi: 10.1111/imr.12344

Fig. 3. Cis and trans interactions between CD22 and its ligands.

Fig. 3

(i) CD22 can engage its ligands in cis on the same cell. A sialic acid bearing glycan on CD22 itself is the primary physiological cis ligand of CD22. (ii) Trans interactions of CD22 with glycan ligands presented on other cells or glycoproteins are also possible.