Skip to main content
. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Immunol Rev. 2016 Jan;269(1):145–161. doi: 10.1111/imr.12344

Fig. 4. Model of CD22 action.

Fig. 4

(i) The majority of CD22 molecules are sequestered away from the BCR by cis interactions. (ii) Loss of CD22 ligands as in ST6GAL1−/− mice disrupts cis interactions, freeing up more CD22 to interact with and inhibit the BCR in a glycan-independent manner. (iii) The R130E mutation in the CD22 ligand-binding domain, that disrupts glycan-binding, also disrupts cis interactions among CD22 moleules, resulting in greater BCR signal inhibition.