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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Immunol Rev. 2016 Jan;269(1):145–161. doi: 10.1111/imr.12344

Fig. 7. Immunodulatory role of Fc glycan sialylation.

Fig. 7

IgGs with sialylated Fc glycans engage DC-SIGN on regulatory macrophages or other innate immune cells. This interaction, via a cascade of events involving the production of secreted mediators such as IL-4, IL-33, alters the balance of activating and inhibitory FcγRs on effector macrophages. Signaling through inhibitory FcγRs predominates, resulting in the dampening of inflammation.