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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Immunol Rev. 2016 Jan;269(1):145–161. doi: 10.1111/imr.12344

Fig. 8. Recognition of enodogenous danger signals by the Siglec-G/CD24 complex.

Fig. 8

CD24 is a cis ligand of Siglec-G on dendritic cells. The Siglec-G/CD24 complex recognizes endogenous danger signals (alarmins) resulting in inhibitory signaling mediated by Siglec-G that dampens immune activation. It can also suppress TLR-mediated signaling in response to PAMPs such as LPS.