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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Prog Retin Eye Res. 2015 Sep 4;51:69–89. doi: 10.1016/j.preteyeres.2015.09.002

Figure 2. Disrupted phagocytosis with Nuc1 depletion.

Figure 2

(A, B) Transmission electron microscopy of RPE from 1-yr old wild type rats shows normal accumulation of lipofuscin-like particles (arrows) in the apical cytoplasm of RPE cells. (C) At higher magnification, RPE cells from 1 year old Nuc1 animals show abundant lipofuscin-like aggregates in the cytoplasm (arrows) and a large phagosome containing undigested outer segment discs (arrowhead). Scale bar = 500 nm. Reprinted with permission of J Cell Science.