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Steps for segregation and elimination of damaged mitochondria includes: (1) Mitochondrial damage (star) followed by fission isolates damaged mitochondria. (2) Pink1 accumulates on damaged mitochondria and recruits Parkin, which ubiquitinates mitofusion. (3) Ub-mitofusion is degraded by the proteasome. (4) Reduced mitofusion prevent fusion of damaged with healthy mitochondria. (5) Damaged mitochondria are targeted for mitophagy.
