Table 2.
Protein profile expression
| Protein | Folds | p value |
|---|---|---|
| Cytokines | ||
| IL10 | 23.81 | 2.84E−07 |
| IL6 | 14.57 | 2.84E−07 |
| IL5 | 13.27 | 2.84E−07 |
| IL7 | 12.51 | 2.84E−07 |
| IL12p70 | 8.74 | 2.84E−07 |
| IL12p40 | 7.72 | 2.84E−07 |
| IL3 | 4.43 | 2.84E−07 |
| IL21 | 3.71 | 2.84E−07 |
| IL4 | 3.70 | 2.84E−07 |
| IL33 | 3.25 | 2.84E−07 |
| TNFα | 2.48 | 5.52E−07 |
| γIFN | 2.28 | 5.52E−07 |
| IL15 | 2.22 | 2.84E−07 |
| IL2 | 2.14 | 5.52E−07 |
| IL1β | 1.71 | 1.10E−04 |
| IL17 | 1.64 | 1.06E−05 |
| IL8 | 1.45 | 3.18E−06 |
| IL34 | 1.34 | 1.70E−03 |
| IL9 | 1.01 | NSS |
| IL18 | −11.79 | 2.16E−05 |
| IL16 | −43.65 | 5.03E−06 |
| Neurotrophins, fibrogenic, and angiogenic factors | ||
| VEGF | 6.10 | 9.01E−07 |
| TGFβ1 | 6.07 | 2.84E−07 |
| NT3 | 4.73 | 3.08E−07 |
| βFGF | 3.92 | 1.84E−04 |
| βNGF | 3.84 | 2.84E−07 |
| Insulin | 3.33 | 1.46E−06 |
| BDNF | 3.13 | 2.84E−07 |
| NT4 | 2.96 | 2.84E −07 |
| SCF | 1.32 | NSS |
| EGF | −1.51 | NSS |
| ECM metabolism | ||
| MMP2 | 3.18 | 2.84E−07 |
| MMP1 | 2.00 | 2.84E−07 |
| TIMP2 | 1.79 | 5.03E−06 |
| MMP13 | 1.27 | NSS |
| TIMP4 | −1.28 | NSS |
| MMP9 | −1.35 | NSS |
| MMP7 | −2.03 | 2.81E−04 |
| TIMP1 | −2.18 | 8.76E−04 |
| Chemokines/adhesion molecules | ||
| VCAM1 | 7.29 | 2.84E−07 |
| MIP1δ | 7.04 | 3.35E−07 |
| MIP1α | 5.51 | 2.84E−07 |
| Eotaxin1 | 2.61 | 3.18E−06 |
| ICAM1 | 2.16 | 1.51E−05 |
| TACE | 2.01 | 2.84E−07 |
| RANTES | 1.94 | 1.23E−03 |
| ICAM2 | 1.91 | 1.88E−05 |
| Eotaxin2 | 1.69 | NSS |
| MIP3β | 1.50 | 5.83E−03 |
| NCAM1 | 1.46 | NSS |
| MIP3α | −1.14 | NSS |
| MIP1β | −1.73 | 1.84E−04 |
| ICAM3 | −8.90 | 6.50E−07 |
| Other molecules | ||
| sTNFR I | 4.41 | 4.68E−07 |
| Albumin | 1.84 | NSS |
| S100B | 1.80 | 5.83E−03 |
| IP10 | 1.77 | 1.41E−05 |
| sTNFR II | 1.03 | NSS |
| TLR2 | −1.21 | 3.26E−01 |
Mann–Whitney U test analysis with both POAG/ctr fold-changes (≥2) and p values (≤0.00083, see “Methods” section) for each biomarker in POAG TMs. NSS for results having p values >8.3E−04. The factors are listed for higher to lower expression. The ECM metabolism cluster included both metalloproteinases and their specific inhibitors, and the cluster other molecules comprised soluble receptors and some referring proteins
BDNF brain-derived neurotrophic factor, ECM extracellular matrix, EGF epidermal growth factor, FGF fibroblast growth factor, ICAM intercellular adhesion molecule, IFN interferon, IL interleukin, IP interferon gamma-induced protein, MIP macrophage inflammatory protein, MMP matrix metalloproteinase, NCAM neural cell adhesion molecule, NGF nerve growth factor, NSS not statistically significant, NT neurotrophin, POAG primary open angle glaucoma, RANTES regulated on activation, normal T cell expressed and secreted, SCF stem cell factor, sTNFR soluble tumor necrosis factor receptor, TACE TNF-α converting enzyme, TLR toll-like receptor, TIMP tissue inhibitor of metalloproteinase, TNF tumor necrosis factor, TM trabecular meshwork, VCAM vascular cell adhesion molecule, VEGF vascular endothelial growth factor