Table 2.

Effects of treatments on serum E₂ levels in NAM rats as compared with normal 4-month-old female rats and untreated NAM rats ($\overline{x}\pm \mathrm{s}\mathrm{d}$) (n = 10 per arm).

Rat group	E2 (pg/mL)
	Before treatment	After treatment
Normal control	72.80 ± 28.29	69.78 ± 19.68∗∗∗
NAM (untreated)	38.23 ± 11.50∗∗	39.68 ± 13.32
Low-dose	45.17 ± 15.63∗∗	66.41 ± 14.27∗∗∗
Middle-dose	48.81 ± 27.63∗∗	92.50 ± 23.88∗∗∗
High-dose	40.84 ± 10.17∗∗	70.50 ± 9.34∗∗∗
Progynova	42.01 ± 13.07∗∗	71.36 ± 8.96∗∗∗

  ^∗∗ P < 0.01 versus normal control group; ^∗∗∗ P < 0.001 versus NAM group.