Figure 4.

Administration of L. angustifolia decreased GFAP expression in the rat spinal cord contusion model transplanted HUMSCs. Intraperitoneal administration of L. angustifolia extract daily for 14 consecutive days postinjury significantly decreased the levels of GFAP expression in the rat spinal cord contusion model. Data are represented as the mean ± S.E.M. (a) ^∗, ^∗∗, and ^∗∗∗ show significant differences between HUMSCs, HUMSCs + Lav 100, 200, and 400, and SCI (Control 1) (P < 0.05, P < 0.0001, and P < 0.0001, resp.). ^### shows significant differences between HUMSCs and HUMSCs + Lav 400 (P < 0.0001) (Per 35625 μm²). (b) Transverse section of spinal cord showing the ventral horn gray matter at the T12-L1 level for all groups on day 56 GFAP-stained images. Yellow arrows indicate VHMNs. Red arrows indicate the GFAP astrocytes. Decreased GFAP astrocytes and increased VHMNs are evident. Bar in 40X = 100 micrometer and bar in 200X = 50 micrometer. (ECLIPSE 5Oi microscope).