Table.
Subject: Eye | Center (coded) | Gestational age at birth (weeks) | Birth weight (grams) | Gestational age at time of treatment (weeks) | Clinical diagnosis | “Reference standard” diagnosis (when available) | Indication(s) for treatment |
---|---|---|---|---|---|---|---|
1: OS | A | 25 | 600 | 42 | Zone II, Stage 2, Pre-plus (mild ROP) | Zone II, Stage 2, No plus (mild ROP) |
|
2: OS | A | 25 | 740 | 39 | Zone II, Stage 2, No plus (mild ROP) | Zone II, Stage 2, Pre-plus (mild ROP) |
|
3: OD | B | 27 | 990 | 47 | Zone II, Stage 3, No Plus (Type 2 ROP) | Zone II, Stage 3, Pre plus (Type 2 ROP) |
|
3: OS | B | 27 | 990 | 47 | Zone II, Stage 3, No Plus (Type 2 ROP) | Zone II, Stage 3, Pre-plus (Type 2 ROP) |
|
4: OD | C | 23 | 534 | 38 | Zone II, Stage 3, No Plus (Type 2 ROP) | N/A |
|
4: OS | C | 23 | 534 | 38 | Zone II, Stage 3, No Plus (Type 2 ROP) | N/A |
|
5: OD | B | 23 | 510 | 40 | Zone II, Stage 3, Pre-plus (Type 2 ROP) | N/A |
|
5: OS | B | 23 | 510 | 40 | Zone II, Stage 3, Pre-plus (Type 2 ROP) | N/A |
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6: OS | D | 26 | 950 | 42 | Zone II, Stage 3, No Plus (Type 2 ROP) | Zone II, Stage 3, No plus (Type 2 ROP) |
|
7: OD | B | 25 | 840 | 41 | Zone II, Stage 3, No Plus (Type 2 ROP) | Zone II, Stage 3, Pre-Plus (Type 2 ROP) |
|
7: OS | B | 25 | 840 | 41 | Zone II, Stage 3, No Plus (Type 2 ROP) | Zone II, Stage 3, Pre-Plus (Type 2 ROP) |
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8: OD | C | 26 | 1090 | 43 | Zone III, Stage 3, No Plus (mild ROP) | N/A |
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9: OS | B | 28 | 1077 | N/A (12 months of age) | Zone III, Stage 1, No plus; peripheral ischemia on fluorescein angiography (mild ROP) | Zone II, Stage 2, No Plus (mild ROP) |
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A prospectively collected database of all neonates screened for retinopathy of prematurity (ROP) from 6 major ROP centers in the United States was retrospectively reviewed to identify cases of treatment with laser or anti-vascular endothelial growth factor agents for ROP milder than Type 1 ROP. The charts of these patients were reviewed to determine the clinical diagnosis and indication for treatment. Table 1 describes each subject and eye treated for ROP milder than Type 1, the center where the patient was diagnosed (coded), gestational age and birth weight, clinical diagnosis and indication for treatment, as well as the “reference standard” diagnosis determined based on review of fundus photographs, when available. Abbreviations: OD: right eye, OS: left eye; ROP: retinopathy of prematurity. Center names have been de-identified and coded A–D