Table 4.

Crude Rates and Multivariable Adjusted ORs for In-Hospital Mortality and Major Bleeding by CKD Stage

	GFR ≥60 ml/min/1.73 m2 (n = 28,029)	Stage 3 (n = 10,168)	Stage 4 (n = 930)	Stage 5 (n = 947)
Death	0.6 (171)	2.8 (284)	6.1 (57)	3.9 (37)
Death adjusted *	1.0 (reference)	2.0 (1.6–2.5)	2.8 (2.0–4.1)	2.6 (1.7–4.1)
Major bleeding	5.5 (1,557)	12.8 (1,300)	30.2 (281)	22.3 (211)
Major bleeding adjusted†	1.0 (reference)	1.5 (1.4–1.6)	2.8 (2.4–3.3)	1.8 (1.5–2.2)

Values are % (n) or OR (95% CI).

^*Multivariable model for death adjusted for: age, prior peripheral arterial disease, SBP on presentation, HF or shock on admission (HF only, shock only, or HF with shock, vs. none), heart rate on presentation, initial troponin ratio, and ECG findings (ST-segment changes vs. no ST-segment changes).

^†Multivariable model for major bleeding adjusted for: age, female sex, diabetes, prior peripheral arterial disease, body weight, home warfarin use, SBP on presentation (SBP ≤130 mm Hg, SBP 130 to 160 mm Hg, and SBP ≥160 mm Hg), heart rate on presentation, HF on presentation (HF only, shock only or HF with shock, vs. none), baseline hemoglobin <12 g/dl (vs. ≥ 12 g/dl), and ECG findings (ST-segment changes vs. no ST-segment changes).

CI = confidence interval; ECG = electrocardiogram; HF = heart failure; OR = odds ratio; other abbreviations as in Table 1.