Table 1.
Demographic data and prior history of study participants
| BMI <25 kg/m2 | BMI 25–30 kg/m2 | BMI ≥30 kg/m2 | p Value | |
|---|---|---|---|---|
| Age (years) | 67 (57–74) | 65 (56–72) | 61 (54–69) | <0.001 |
| % Women | 499 (36.3) | 827 (29.5) | 932 (40.6) | <0.001 |
| Waist circumference (cm) | 89 (82–95) | 99 (92–105) | 110 (104–119) | <0.001 |
| Region | ||||
| North America | 180 (13.1) | 392 (14) | 518 (22.6) | <0.001 |
| Eastern Europe | 487 (35.5) | 1093 (39) | 901 (39.3) | <0.001 |
| Western Europe | 706 (51.4) | 1319 (47) | 874 (38.1) | <0.001 |
| Risk factors | ||||
| Hypertension | 875 (64.4) | 1991 (71.6) | 1881 (82.3) | <0.001 |
| Dyslipidaemia | 770 (61) | 1705 (66.9) | 1525 (72.5) | <0.001 |
| Diabetes | 318 (23.2) | 812 (29) | 1059 (46.2) | <0.001 |
| Current smoker | 407 (29.7) | 719 (25.6) | 534 (23.3) | 0.01 |
| Prior CVD | ||||
| Congestive heart failure | 207 (15.1) | 453 (16.2) | 429 (18.7) | 0.31 |
| Peripheral vascular disease | 139 (10.2) | 248 (9) | 173 (7.6) | 0.04 |
| Cerebrovascular disease | 162 (11.8) | 294 (10.5) | 243 (10.6) | 0.79 |
| Prior stroke | 81 (5.9) | 137 (4.9) | 110 (4.8) | 0.63 |
| Index diagnosis | ||||
| Unstable angina | 598 (43.6) | 1283 (45.8) | 1154 (50.3) | 0.03 |
| NSTEMI | 748 (54.5) | 1461 (52.1) | 1078 (47) | 0.03 |
| Other | 27 (2) | 60 (2.1) | 61 (2.7) | 0.03 |
| Presentation | ||||
| ST depression ≥1 mm | 534 (38.9) | 1018 (36.3) | 725 (31.6) | <0.001 |
| Troponin ≥0.04 mcg/l | 647 (70.5) | 1269 (66.6) | 964 (59) | <0.001 |
| BNP >80 pg/ml | 466 (50.4) | 825 (43) | 608 (37) | <0.001 |
| eGFR <60 ml/min | 565 (41.3) | 578 (20.7) | 241 (10.5) | <0.001 |
| Fasting blood glucose (mg/dl) | 101 (88–124) | 105 (92–128) | 114 (97–148) | <0.001 |
| Heart rate (bpm) | 70 (61–78) | 70 (62–78) | 70 (63–80) | <0.001 |
| LVEF (%)* | 55 (47–61) | 55 (47–60) | 55 (47–60) | 0.67 |
| Disease extent (≥50%)† | ||||
| LM or 3VD | 286 (35.2) | 597 (35.4) | 470 (34.6) | 0.34 |
| 2VD | 190 (23.4) | 440 (26.1) | 340 (25) | 0.34 |
| 1VD | 232 (28.6) | 473 (28.1) | 373 (27.5) | 0.34 |
| None | 104 (12.8) | 176 (10.4) | 175 (12.9) | 0.34 |
Data are reported as median (25th, 75th percentiles) for continuous variables and N (%) for categorical variables.
*
Among 4383 patients with LVEF available.
†
Among 3856 patients with angiographic data available.
1VD, one vessel disease; 2VD, two vessel disease; 3VD, three vessel disease; BNP, B-type natriuretic peptide; eGFR, estimated glomerular filtration rate; LM, left main; LVEF, left ventricular ejection fraction.