TABLE 1.
Demographic, clinical, and body composition characteristics in 32 subjects with cystic fibrosis
| Variable | Cystic Fibrosis (n = 32) |
Reference (n = 20) |
P |
|---|---|---|---|
| Age (y) | 26.1 ± 8.9 | 30.9 ± 8.8 | 0.12 |
| Female (%) | 18 (56) | 8 (40) | 0.39 |
| Caucasian/White Race (%) | 30 (93.8) | 15 (75) | 0.02 |
| Glucose Tolerance | |||
| Normal glucose tolerance (%) | 14 (43.8) | 13 (65) | 0.003 |
| Prediabetes (%) | 6 (18.8) | 7 (35) | |
| Diabetes (%) | 12 (37.5) | 0 (0) | |
| FEV1 (% predicted) | 80.4 ± 21.5 | ---------------- | -------- |
| Lung function status1 | -------- | ||
| Normal (%) | 20 (62.5) | ---------------- | |
| Mild (%) | 4 (12.5) | ---------------- | |
| Moderate/severe (%) | 8 (25.0) | ---------------- | |
| Pancreatic insufficiency (%) | 31 (96.9) | ---------------- | -------- |
| Age of CF diagnosis (y)2 | 1.5 (0.6-5.0) | ---------------- | -------- |
| Genotype | -------- | ||
| ΔF508Homozygous (%) | 18 (56.3) | ---------------- | |
| ΔF508 Heterozygous (%) | 9 (28.1) | ---------------- | |
| Other (%) | 5 (15.6) | ---------------- | |
| Height (cm) | 165.6 ± 9.9 | 173.7 ± 11.0 | 0.009 |
| Body weight (kg) | 60.9 ± 11.9 | 74.4 ± 16.9 | 0.001 |
| Body mass index (kg/m2) | 22.1 ± 2.9 | 24.5 ± 3.7 | 0.01 |
| Fat-free mass (kg) | 45.0 ± 10.0 | 55.5 ± 13.4 | 0.002 |
| Fat-free mass index (kg/m2) | 16.2 ± 2.0 | 18.2 ± 2.8 | 0.006 |
| Fat mass (kg) | 15.9 ± 5.7 | 18.9 ± 7.3 | 0.11 |
| Fat mass index (kg/m2) | 5.9 ± 2.2 | 6.3 ± 2.4 | 0.47 |
| Body fat (%) | 26.1 ± 7.6 | 25.4 ± 8.1 | 0.75 |
| Body composition category | |||
| Lean (%) | 16 (50) | 6 (30) | 0.13 |
| Normal weight obesity (%) | 10 (31.3) | 5 (25) | |
| Overweight/obese (%) | 6 (18.8) | 9 (45) |
Values are reported as mean ± SD or n (%).
1
Lung function status defined according to FEV1 (% predicted): <59%, moderate; 60-79%, mild; ≥ 80%, normal.
2
Reported as median (IQR)