TABLE 3.

Cox regression hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between blood levels of lipid-corrected PCBs and 15-year mortality in the LIBCSP women diagnosed with breast cancer in 1996–1997.

PCB	All-cause Mortality					Breast Cancer-specific Mortality
	Deaths	Censored	HRAdja	95% CI	PTrendb	Deaths	Censored	HRAdja	95% CI	PTrendb
Wolff Group 1B (Potentially estrogenic, persistent)
ΣGroup 1B – The 4- or 4′-position is unchlorinated on one phenyl ring
Tertile 1	58	150	1			27	181	1
Tertile 2	63	146	0.98	(0.67–1.43)		19	190	0.72	(0.39–1.31)
Tertile 3	65	144	0.92	(0.63–1.35)	0.93	28	181	1.16	(0.65–2.05)	0.22
PCB101 – 2,2′,4,5,5′
Tertile 1	54	142	1			22	174	1
Tertile 2	62	135	1.15	(0.79–1.66)		19	178	0.86	(0.46–1.60)
Tertile 3	58	138	1.14	(0.78–1.66)	0.73	29	167	1.33	(0.76–2.33)	0.42
PCB174 – 2,2′,3,3′,4,5,6′
Tertile 1	66	142	1			19	189	1
Tertile 2	61	148	0.95	(0.70–1.35)		24	185	1.27	(0.69–2.32)
Tertile 3	59	150	1.09	(0.77–1.56)	0.90	31	178	1.88	(1.05–3.36)	0.12
PCB177 – 2,2′,3,3′,4′,5,6
Tertile 1	59	149	1			18	190	1
Tertile 2	62	147	1.12	(0.78–1.61)		30	179	1.79	(1.00–3.23)
Tertile 3	65	144	1.18	(0.82–1.69)	0.35	26	183	1.71	(0.93–3.15)	0.02
PCB187 – 2,2′,3,4′,5,5′,6
Tertile 1	64	144	1			30	178	1
Tertile 2	52	157	0.69	(0.47–1.00)		20	189	0.70	(0.39–1.25)
Tertile 3	70	139	0.86	(0.60–1.25)	0.27	24	185	0.90	(0.50–1.61)	0.99
PCB199 – 2,2′,3,3′,4′,5,5′,6
Tertile 1	56	152	1			27	181	1
Tertile 2	55	154	0.88	(0.60–1.30)		21	188	0.88	(0.49–1.59)
Tertile 3	76	133	1.04	(0.70–1.56)	0.70	26	183	1.26	(0.68–2.32)	0.29
Wolff Group 2A (Potentially anti-estrogenic, persistent)
ΣGroup 2A – The 4- and 4′-positions are chlorinated on both phenyl rings and one phenyl ring has an unchlorinated 2-position
Tertile 1	63	141	1			29	175	1
Tertile 2	57	148	0.66	(0.44–0.99)		24	181	0.84	(0.45–1.55)
Tertile 3	65	139	0.60	(0.39–0.83)	0.59	21	183	0.72	(0.37–1.42)	0.86
PCB66 – 2,3′,4,4′
Tertile 1	48	122	1			16	154	1
Tertile 2	57	114	1.16	(0.79–1.71)		27	144	1.71	(0.92–3.19)
Tertile 3	52	119	1.10	(0.74–1.63)	0.74	18	153	1.10	(0.55–2.16)	0.45
PCB74 – 2,4,4′,5
Tertile 1	55	149	1			27	177	1
Tertile 2	59	146	0.83	(0.56–1.21)		25	180	0.93	(0.53–1.62)
Tertile 3	71	134	0.91	(0.62–1.34)	0.57	22	183	0.86	(0.47–1.57)	0.76
PCB105 – 2,3,3′,4,4′
Tertile 1	58	147	1			29	176	1
Tertile 2	53	152	0.83	(0.57–1.22)		20	185	0.71	(0.40–1.26)
Tertile 3	74	131	1.17	(0.83–1.67)	0.46	25	180	0.92	(0.54–1.59)	0.73
PCB118 – 2,3′,4,4′,5
Tertile 1	62	146	1			26	182	1
Tertile 2	55	154	0.78	(0.54–1.12)		24	185	0.93	(0.53–1.63)
Tertile 3	70	139	0.63	(0.43–0.92)	0.32	24	185	0.96	(0.51–1.79)	0.39
Wolff Group 2B (Potentially anti-estrogenic, limited dioxin activity, persistent)
ΣGroup 2B – The 6- and 6′-positions are unchlorinated
Tertile 1	62	146	1			26	182	1
Tertile 2	55	153	0.72	(0.49–1.05)		23	185	0.86	(0.48–1.55)
Tertile 3	70	138	0.80	(0.55–1.16)	0.09	25	183	1.00	(0.55–1.81)	0.91
PCB138 – 2,2′,3,4,4′,5′
Tertile 1	57	136	1			27	166	1
Tertile 2	57	136	0.77	(0.52–1.12)		18	175	0.65	(0.35–1.19)
Tertile 3	64	129	0.79	(0.54–1.16)	0.09	27	166	1.07	(0.60–1.89)	0.81
PCB170 – 2,2′,3,3′,4,4′,5
Tertile 1	64	143	1			27	180	1
Tertile 2	57	150	0.82	(0.57–1.19)		25	182	0.97	(0.56–1.70)
Tertile 3	65	142	0.82	(0.55–1.20)	0.29	22	185	0.88	(0.48–1.61)	0.42
Wolff Group 3 (CYP1A1 and CYP2B inducers, biologically persistent)
ΣGroup 3 – The 2- and 2′- and 4 and 4′-positions are chlorinated and the 5 or 5′-position is chlorinated
Tertile 1	58	151	1			22	187	1
Tertile 2	63	146	0.93	(0.62–1.39)		31	178	1.63	(0.89–3.00)
Tertile 3	66	143	0.85	(0.56–1.28)	0.52	21	188	1.13	(0.57–2.26)	0.51
PCB99 – 2,2′,4,4′,5
Tertile 1	46	151	1			18	179	1
Tertile 2	59	139	1.14	(0.77–1.70)		27	171	1.57	(0.85–2.90)
Tertile 3	69	129	1.11	(0.75–1.64)	0.99	23	175	1.39	(0.73–2.64)	0.69
PCB153 – 2,2′,4,4′,5,5′
Tertile 1	57	150	1			23	184	1
Tertile 2	64	144	0.96	(0.66–1.39)		29	179	1.39	(0.79–2.43)
Tertile 3	65	143	0.82	(0.55–1.21)	0.38	22	186	1.07	(0.57–2.00)	0.57
PCB180 – 2,2′,3,4,4′,5,5′
Tertile 1	59	150	1			26	183	1
Tertile 2	57	152	0.82	(0.56–1.20)		22	187	0.97	(0.53–1.76)
Tertile 3	71	138	0.93	(0.62–1.39)	0.73	26	183	1.29	(0.69–2.41)	0.63
PCB183 – 2,2′,3,4,4′,5′,6
Tertile 1	56	151	1			22	185	1
Tertile 2	62	146	1.05	(0.73–1.52)		25	183	1.21	(0.68–2.16)
Tertile 3	66	142	0.99	(0.69–1.43)	0.80	26	182	1.34	(0.75–2.41)	0.13
PCB203 – 2,2′,3,4,4′,5,5′,6
Tertile 1	56	153	1			25	184	1
Tertile 2	55	154	1.03	(0.70–1.52)		22	187	1.01	(0.56–1.83)
Tertile 3	76	133	1.11	(0.74–1.65)	0.35	27	182	1.42	(0.77–2.62)	0.11

^aAdjusted for age at diagnosis, education, body mass index, and parity/lactation history.

^bNatural log-transformed.