Table 2.
Characteristics at the 2-year follow up, stratified by latent class analysis presented as mean (95% CI) or n (%).
| Variable | N | Analyzed cohort | Trajectory 1: High Fall Risk | Trajectory 2: Medium Fall Risk | Trajectory 3: Low Fall Risk |
|---|---|---|---|---|---|
| MDS-UPDRS-3 (0 to 132) | 168 | 34.8 (32.5, 37.1) | 40.9 (37.0, 44.7) | 34.0 (30.0, 38.0)1 | 27.4 (24.0, 30.9)1,2 |
|
| |||||
| Levodopa equivalent dose (mg/day) | 171 | 689.5(617.9, 761.1) | 798.0 (684.0, 912.0) | 639.4 (520.0, 758.7) | 593.2 (449.5, 737.0) |
|
| |||||
| PASE score (0 to >400)† | 170 | 129.7 (117.5, 141.9) | 102.1 (87.5, 116.6) | 132.9 (111.7, 154.2) | 163.9 (136.6, 191.2)1 |
|
| |||||
| Fall risk category | 165 | 1 | 1,2 | ||
| High | 58 (35.2) | 47 (75.8) | 10 (17.9) | 1 (2.1) | |
| Med | 60 (36.4) | 15 (24.2) | 38 (67.9) | 7 (14.9) | |
| Low | 47 (28.5) | 0 (0) | 8 (14.3) | 39 (83.0) | |
|
| |||||
| Fall history | 170 | 1 | 1,2 | ||
| None | 95 (55.9) | 13 (19.7) | 37 (66.1) | 45 (93.8) | |
| One | 34 (20.0) | 15 (22.7) | 16 (28.6) | 3 (6.3) | |
| Multiple | 41 (24.1) | 38 (57.6) | 3 (5.4) | 0 (0) | |
|
| |||||
| Self-paced gait speed (m/s)† | 166 | 1.12 (1.09, 1.16) | 1.01 (.95, 1.07) | 1.11 (1.05, 1.17)1,2 | 1.30 (1.25, 1.34)1,2 |
|
| |||||
| FOG severity score (0 to 16) | 170 | 3.3 (2.7, 3.9) | 5.9 (5.0, 6.8) | 2.8 (1.8, 3.8)1,2 | .3 (−.1, .6)1,2 |
|
| |||||
| Dyskinesia severity (0 to 8) | 170 | .8 (.6, 1.1) | 1.2 (.8, 1.6) | .7 (.3, 1.1) | .5 (.2, .8)1 |
|
| |||||
| PIGD score (0 to >1.15) | 167 | .85 (.74, .96) | 1.31 (1.12, 1.50) | .74 (.60, .88)1 | .36 (.28, .43)1,2 |
|
| |||||
| Motor subtype | 166 | ||||
| PIGD | 107 (64.5) | 55 (87.3) | 35 (62.5) | 17 (36.2) | |
| Indeterminate | 21 (12.7) | 4 (6.4) | 8 (14.3) | 9 (19.2) | |
| Tremor dominant | 38 (22.9) | 4 (6.4) | 13 (23.2) | 21 (44.7) | |
MDS-UPDRS-3: Part 3 of the Movement Disorders Society-sponsored version of the Unified Parkinson Disease Rating Scale; PASE: Physical Activity Scale for the Elderly; FOG: freezing of gait; PIGD: postural instability and gait disability.
1
Significantly different than the high fall risk trajectory (p<.05)
2
Significantly different than the medium fall risk trajectory (p<.05)
†
High scores indicate better performance