Table 3.
Characteristics of participants with stable (posterior probabilities ≥0.8, n=178) and fluctuating (posterior probabilities <0.8, n=52) fall risk trajectories. Scores are reported as mean (95% CI) or n (%).
| Variable | Baseline | Change over the first 6 months | ||||
|---|---|---|---|---|---|---|
| Stable risk trajectory (Probability ≥80) | Fluctuating risk trajectory (Probability <80) | p-value | Stable risk trajectory (Probability ≥80) | Fluctuating risk trajectory (Probability <80) | p-value | |
| Age (years) | 66.9 (65.5, 68.3) | 67.9 (65.6, 70.2) | .49 | |||
|
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| Disease duration (years since diagnosis) | 6.2 (5.5, 6.9) | 4.8 (3.7, 5.9) | .05 | |||
|
| ||||||
| Levodopa equivalent dose (mg/day) | 589.8 (513.3, 666.4) | 454.1 (364.2, 544.1) | .08 | |||
|
| ||||||
| PIGD score baseline (0 to >1.15) | .83 (.72, .94) | .65 (.53, .77) | .03 | |||
|
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| Motor subtype† | .03 | .99 | ||||
| PIGD / shift | 113 (64%) | 24 (46%) | 92 (57%) | 26 (58%) | ||
| Indeterminate / no change | 12 (7%) | 8 (15%) | 17 (11%) | 5 (11%) | ||
| Tremor dominant / shift | 52 (29%) | 20 (38%) | 52 (32%) | 14 (31%) | ||
|
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| FOG severity score (0 to 16) | 3.2 (2.7, 3.8) | 2.8 (1.8, 3.9) | .52 | .4 (0, 0.7) | .1 (−.8, .9) | .47 |
|
| ||||||
| Self-paced gait speed (m/sec) | 1.18 (1.14, 1.22) | 1.22 (1.17, 1.28) | .21 | −.01 (−03, .02) | −06 (−.12, −.01) | .07 |
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| PASE score (0 to >400) | 146.0 (133.7, 158.4) | 134.6 (114.2, 154.9) | .38 | −6.2 (−16.7, 4.4) | 4.9 (−12.7, 22.4) | .33 |
|
| ||||||
| Fall risk trajectory | .46 | |||||
| High | 73 (74.5) | 25 (25.5) | ||||
| Fall risk score (0 to 11) | 9.0 (8.4, 9.6) | 5.6 (4.4, 6.9) | <.001 | |||
| Medium | 56 (76.7) | 17 (23.3) | ||||
| Fall risk score (0 to 11) | 3.2 (2.6, 3.8) | 3.8 (2.2, 5.5) | .40 | |||
| Low | 49 (83.1) | 10 (16.9) | ||||
| Fall risk score (0 to 11) | 0.4 (−.2, .9) | 1.1 (−.2, 2.4) | .24 | |||
PIGD: postural instability and gait disability; FOG: freezing of gait; PASE: Physical Activity Scale for the Elderly.
LeA side of dash (/) indicates baseline PD subtype, right side of dash indicates shift in subtype, of lack thereof, over 6 months.