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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: Bioorg Med Chem. 2016 Feb 3;24(6):1314–1321. doi: 10.1016/j.bmc.2016.02.002

Scheme 1.

Scheme 1

Reagents and conditions: (a) CBr4, PPh3, NaN3, DMF, 0 °C to rt, 24 h, 78%; (b) TBSCl, imidazole, DMAP, DMF, rt, 7 h, 80%; (c) Pd/C, H2, MeOH, rt, 4–6 h; (d) sulfamide, 1,4-dioxane, reflux, 13–17 h, 85% (13 to 14), 58% (12 to 15); (e) 4 M HCl in 1,4-dioxane, MeOH, rt, 3 h, quant.