A. Representative images of tailing of damaged DNA show that 1-D2/CA combination alone has no apparent effect on AML cells. As expected, there is evidence of DNA damage when the cells are exposed to AraC alone, 100 nM for 72 h and maintained in normal medium for additional 96 h, (center panels). DNA damage is increased when AraC is followed by 1-D2 (100 nM) and CA (10 uM) for 96 h (right side panels). B. Quantitation of comet tails, as described in M & M. # = p <0.05 when compared to control; * = p < 0.01, compared with AraC-treated group; n=3.