Table 1.

Statistical significance of the effects of AraC vs combinations of AraC, CA and 1-D2.

	HL60 cells				U937 cells
Treatment groups	Average±SD Apoptosis	P value vs AraC	P value vs AraC-CA	P value vs AraC-1-D2	Average Apoptosis	P value vs AraC	P value vs AraC-CA	P value vs AraC-1-D2
Ara-C-100 nM-Cotnrol	17.1% ± 5.8%				14.3% ± 4.7%
Ara-C-72hr-CA-96hr	19.2% ± 6.1%	0.083			15.9% ± 2.3%	0.252
Ara-C-72hr-1-D2-96hr	18.3% ± 8.3%	0.573			17.8% ± 4.0%	0.081
Ara-C-72hr-CAD2-96hr	28.3% ± 5.6%	0.008	0.004	0.003	25.5% ± 5.9%	0.002	0.011	0.024
	Necrosis				Necrosis
Ara-C-100 nM-Cotnrol	15.3% ± 7.9%				18.6% ± 3.9%
Ara-C-72hr-CA-96hr	16.1% ± 6.9%	0.540			20.5% ± 7.2%	0.272
Ara-C-72hr-1-D2-96hr	18.5% ± 8.2%	0.158			21.0% ± 5.9%	0.119
Ara-C-72hr-CAD2-96hr	22.5% ± 9.8%	0.010	0.008	0.073	25.8% ±	0.118	0.232	0.156
	Total death				Total death
Ara-C-100 nM-Cotnrol	32.4% ± 9.4%				32.9% ± 2.5%
Ara-C-72hr-CA-96hr	35.3% ± 10.3%	0.012			36.4% ± 5.3%	0.208
Ara-C-72hr-1-D2-96hr	36.8% ± 9.6%	0.192			38.8% ± 4.1%	0.042
Ara-C-72hr-CAD2-96hr	50.8% ± 10.2%	0.001	0.002	0.001	51.3% ± 5.7%	0.003	0.002	0.004