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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Metab Eng. 2015 Jul 17;31:123–131. doi: 10.1016/j.ymben.2015.06.011

Figure 2. Direction of flux in dynamic and precision metabolic engineering.

Figure 2

A) Dynamic control redirects flux based on a change in the system. The pathway flux distribution changes, but flux may still be permitted through competing pathways. Initially, the majority of the metabolic flux is through the left branch of the pathway, with some flux permitted through the right branch. Upon initiation of a change, the flux shifts so that the majority is through the right branch. Circles represent metabolites in the pathway, with solid circles indicating significant production of a metabolite and dotted circles indicating partial repression of its production.

B) Rather than emphasizing the ability to dynamically switch between metabolic states, precision metabolic engineering emphasizes the completeness of the switch in metabolic state. Competing pathways are completely repressed so that only the desired metabolic pathway is active.