Table 2.

Oxycodone–naloxone PR in special populations

Renal impairment	Should be used with caution in patients with impaired renal function
Hepatic impairment	Should be used with caution in patients with mild hepatic dysfunction; contraindicated in patients with moderate and severe hepatic impairment
Pregnancy, labor, and delivery	Contraindicated during pregnancy, labor, and delivery, due to impaired uterine contractility and the risk of neonatal respiratory depression
Nursing women	Safety in infants and newborns has not been studied; therefore, it is contraindicated in nursing mothers
Pediatric population	Safety and effectiveness in pediatric patients not established
Geriatric population	Dosage should be adjusted to the lowest dose, which will achieve satisfactory symptom relief with acceptable side effects

Abbreviation: PR, prolonged release.