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. 2016 Feb 24;7:10618. doi: 10.1038/ncomms10618

Figure 2. Binding affinities of the indicated germline VRC01-class antibodies to selected 426c variants.

Figure 2

Soluble trimeric 426c gp140 variants were biotinylated and immobilized on a streptavidin biosensor. The association constant of the various germline VRC01-class antibodies was determined by BLI, as described in the Methods section. Undetectable antibody-Env binding is shown on the x axis. Full kinetic parameters are shown in Supplementary Table 1. See Table 1 for a description of the various mutations on the 426c Env.